An interprofessional and longitudinal approach is being piloted at the University of Texas Medical Branch at Galveston as part of a large state-funded initiative in health care transformation and quality improvement. The goal is to train clinicians to be effective team members and leaders in a patient-centered medical home environment during their careers. This type of program is similar in many ways to the longitudinal integrated clerkship, an approach to the core clinical experiences that replaces a sequence of specialty-specific blocks of time with the student working with a defined cohort of patients for 1 year or more. The emphasis is on longitudinal integration of curricular experiences and continuity with patients and teachers. Focusing on the practice environment allows greater emphasis on peer-to-peer interaction and deeper integration with the practice environment, its faculty, and staff, that extends throughout the students’ entire medical school experience. This longstanding immersion in the work of a primary care practice thus highlights issues related to their role as health care practitioners.